Sodium fluoride 250gr
Sodium fluoride 250gr
Sodium fluoride (NaF) is an inorganic compound with the formula NaF. It is used in trace amounts in the fluoridation of drinking water, toothpaste, in metallurgy, as a flux, and is also used in pesticides and rat poison. It is a colorless or white solid that is readily soluble in water. It is a common source of fluoride in the production of pharmaceuticals and is used to prevent dental cavities.
In 2017, it was the 247th most commonly prescribed medication in the United States, with more than one million prescriptions
Properties
Properties | |
---|---|
NaF | |
Molar mass | 41.988173 g/mol |
Appearance | White to greenish solid |
Odor | odorless |
Density | 2.558 g/cm3 |
Melting point | 993 °C (1,819 °F; 1,266 K) |
Boiling point | 1,704 °C (3,099 °F; 1,977 K) |
36.4 g/L (0 °C); 40.4 g/L (20 °C); 50.5 g/L (100 °C)[2] | |
Solubility | slightly soluble in HF, ammonia negligible in alcohol, acetone, SO2, dimethylformamide |
Vapor pressure | 1 mmHg @ 1077 C°[3] |
−16.4·10−6 cm3/mol | |
Refractive index (nD) | 1.3252 |
Chemical Structure Sodium Fluoride 250gr
Safety
The lethal dose for a 70 kg (154 lb) human is estimated at 5–10 g.[19]
Fluorides, particularly aqueous solutions of sodium fluoride, are rapidly and quite extensively absorbed by the human body.[22]
Fluorides interfere with electron transport and calcium metabolism. Calcium is essential for maintaining cardiac membrane potentials and in regulating coagulation. Large ingestion of fluoride salts or hydrofluoric acid may result in fatal arrhythmias due to profound hypocalcemia. Chronic over-absorption can cause hardening of bones, calcification of ligaments, and buildup on teeth. Fluoride can cause irritation or corrosion to eyes, skin, and nasal membranes.[23]
Sodium fluoride is classed as toxic by both inhalation (of dusts or aerosols) and ingestion.[24] In high enough doses, it has been shown to affect the heart and circulatory system. For occupational exposures, the Occupational Safety and Health Administration and the National Institute for Occupational Safety and Health have established occupational exposure limits at 2.5 mg/m3 over an eight-hour time-weighted average.[25]
Lethal Dose Sodium Fluoride 250gr
In the higher doses used to treat osteoporosis, plain sodium fluoride can cause pain in the legs and incomplete stress fractures when the doses are too high; it also irritates the stomach, sometimes so severely as to cause ulcers. Slow-release and enteric-coated versions of sodium fluoride do not have gastric side effects in any significant way, and have milder and less frequent complications in the bones.[26] In the lower doses used for water fluoridation, the only clear adverse effect is dental fluorosis, which can alter the appearance of children’s teeth during tooth development; this is mostly mild and is unlikely to represent any real effect on aesthetic appearance or on public health.[27] A chronic fluoride ingestion of 1 ppm of fluoride in drinking water can cause mottling of the teeth (fluorosis) and an exposure of 1.7 ppm will produce mottling in 30–50 % of patients.
Description
Osteoporosis
Fluoride supplementation has been extensively studied for the treatment of postmenopausal osteoporosis. This supplementation does not appear to be effective; even though sodium fluoride increases bone density, it does not decrease the risk of fractures.[13][14]
Medical imaging
In medical imaging, fluorine-18-labelled sodium fluoride (USP, sodium fluoride F18) is one of the oldest tracers used in positron emission tomography (PET), having been in use since the 1960s.[15] Relative to conventional bone scintigraphy carried out with gamma cameras or SPECT systems, PET offers more sensitivity and spatial resolution. Fluorine-18 has a half-life of 110 min, which requires it to be used promptly once produced; this logistical limitation hampered its adoption in the face of the more convenient technetium-99m-labelled radiopharmaceuticals. However fluorine-18 is generally considered to be a superior radiopharmaceutical for skeletal imaging. In particular it has a high and rapid bone uptake accompanied by very rapid blood clearance, which results in a high bone-to-background ratio in a short time.[16] Additionally the annihilation photons produced by decay of 18F have a high energy of 511-keV compared to 140-keV photons of 99mTc.[17]
Chemistry
Sodium fluoride has a variety of specialty chemical applications in synthesis and extractive metallurgy. It reacts with electrophilic chlorides including acyl chlorides, sulfur chlorides, and phosphorus chloride.[18] Like other fluorides, sodium fluoride finds use in desilylation in organic synthesis. Sodium fluoride can be used to produce fluorocarbons via the Finkelstein reaction; this process has the advantage of being simple to perform on a small scale but is rarely used on an industrial scale due to the existence of more effective techniques (e.g. Electrofluorination, Fowler process).
Other uses
Over a century ago, sodium fluoride was used as a stomach poison for plant-feeding insects.[20] Inorganic fluorides such as fluorosilicates and sodium fluoride complex magnesium ions as magnesium fluorophosphate. They inhibit enzymes such as enolase that require Mg2+ as a prosthetic group. Thus, fluoride poisoning prevents phosphate transfer in oxidative metabolism.